This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicine Scutellaria baicalensis\nfor the treatment of severeHFMDin 725 patients aged >1 year in amulticenter, retrospective analysis.Thepatientswere divided into\nthe S. baicalensis and ribavirin groups, and the temperatures, presence or absence of skin rashes and oral lesions, nervous system\n(NS) involvement, and viral loads of the patients, as well as the safety of the treatments, were evaluated. The median duration of\nfever, median time to NS involvement, and the number of patients with oral ulcers and/or vesicles, as well as skin rashes, were\ndecreased in the S. baicalensis group compared with the ribavirin group. In addition, the EV71 viral loads were decreased in the\nS. baicalensis group, suggesting that S. baicalensis exerted more potent antiviral effects compared with ribavirin. The present study\ndemonstrated that S. baicalensis was suitable for the treatment of severeHFMDin patients aged >1 year, since itwas shown to rapidly\nrelieve fever, attenuate oral lesions and rashes, and improve NS involvement. Furthermore, it was demonstrated to be relatively safe\nfor topical application.
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